
Publications
For a full list of Holt/Geleoc Lab publications, please click on this link:
December 15, 2021
Dual-vector gene therapy restores auditory sensitivity in a mouse model of DFNB16 hearing loss
Olga Shubina-Oleinik, Carl Nist-Lund, Courtney French, Shira Rockowitz, A Eliot Shearer, Jeffrey R Holt
November 4, 2021
Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses
John Lee, Kosuke Kawai, Jeffrey R Holt, Gwenaëlle SG Géléoc
November 4, 2021
Putting the Pieces Together: the Hair Cell Transduction Complex
Jeffrey R Holt, Mélanie Tobin, Johannes Elferich, Eric Gouaux, Angela Ballesteros, Zhiqiang Yan, Zubair M Ahmed, Teresa Nicolson
February 5, 2021
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness
Shahar Taiber, Roie Cohen, Ofer Yizhar‐Barnea, David Sprinzak, Jeffrey R Holt, Karen B Avraham
December 2, 2020
Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice
Jennifer J Lentz , Bifeng Pan , Abhilash Ponnath , Christopher M Tran , Carl Nist-Lund , Alice Galvin , Hannah Goldberg , Katelyn N Robillard , Francine M Jodelka , Hamilton E Farris , Jun Huang , Tianwen Chen , Hong Zhu , Wu Zhou , Frank Rigo , Michelle L Hastings , Gwenaëlle S G Géléoc
November 17, 2020
Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice. Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR.
June 03, 2020
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
Wei-Hsi Yeh*, Olga Shubina-Oleinik*, Jonathan M. Levy, Bifeng Pan, Gregory A. Newby, Michael Wornow, Rachel Burt, Jonathan C. Chen, Jeffrey R. Holt†, David R. Liu1† * co-first authors, †co-senior authors
January 13, 2020
Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B
July 03, 2019
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.
György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, **Holt JR, Corey DP. Nat Med. 2019 Jul;25(7):1123-1130.
**corresponding author
August 22, 2018
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
Bifeng Pan, Nurunisa Akyuz, Xiao-Ping Liu, Yukako Asai, Carl Nist-Lund, Kiyoto Kurima, Bruce H. Derfler, Bence Gyorgy, Walrati Limapichat, Sanket Walujkar, Lahiru N. Wimalasena, Marcos Sotomayor, David P. Corey, and Jeffrey R. Holt, Neuron, 2018 Aug 22;99(4):736-753
Plug-N-Play: Mechanotransduction Goes Modular.
N. Akyuz, J.R. Holt. Neuron 89:1128-30. 2016.
July 11, 2012
The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. J Neurosci. 2012, 32(28):9485-98.