Publications

For a full list of Holt/Geleoc Lab publications, please click on this link:

PubMed Holt/Geleoc Lab

February 5, 2021

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness

Shahar Taiber, Roie Cohen, Ofer Yizhar‐Barnea, David Sprinzak, Jeffrey R Holt, Karen B Avraham

Link to EMBO Article

December 2, 2020

Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

Jennifer J Lentz , Bifeng Pan , Abhilash Ponnath , Christopher M Tran , Carl Nist-Lund , Alice Galvin , Hannah Goldberg , Katelyn N Robillard , Francine M Jodelka , Hamilton E Farris , Jun Huang , Tianwen Chen , Hong Zhu , Wu Zhou , Frank Rigo , Michelle L Hastings , Gwenaëlle S G Géléoc

Link to Molecular Therapy

November 17, 2020

Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice. Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR.

Link to Molecular Therapy

~~June 03, 2020~~

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

Wei-Hsi Yeh*, Olga Shubina-Oleinik*, Jonathan M. Levy, Bifeng Pan, Gregory A. Newby, Michael Wornow, Rachel Burt, Jonathan C. Chen, Jeffrey R. Holt†, David R. Liu1 † * co-first authors, †co-senior authors

Link to publication

~~January 13, 2020~~

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

John Lee, Carl Nist-Lund, Paola Solanes, Hannah Goldberg, Jason Wu, Bifeng Pan, Bernard L Schneider, Jeffrey R Holt

Hearing Research Link

~~July 03, 2019~~

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, **Holt JR, Corey DP. Nat Med. 2019 Jul;25(7):1123-1130.

**corresponding author

Nature Medicine Link

~~January 22, 2019~~

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR.

Nat Commun. 2019 Jan 22;10(1):236. doi: 10.1038/s41467-018-08264-w.

Nature Comms. Article

~~January 11, 2019~~

Split otoferlins reunited

Holt JR, Geleoc GS. EMBO Mol Med. 2019 Jan;11(1). pii: e9995. doi: 10.15252/emmm.201809995.

Link to EMBO Article

~~October 05, 2018~~

Function and Dysfunction of TMC Channels in Inner Ear Hair Cells

Corey DP, Akyuz N, Holt JR. Cold Spring Harb Perspect Med. 2018 Oct 5. pii: a033506. doi: 10.1101/cshperspect.a033506.

Link to PubMed

~~August 22, 2018~~

TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells

Bifeng Pan, Nurunisa Akyuz, Xiao-Ping Liu, Yukako Asai, Carl Nist-Lund, Kiyoto Kurima, Bruce H. Derfler, Bence Gyorgy, Walrati Limapichat, Sanket Walujkar, Lahiru N. Wimalasena, Marcos Sotomayor, David P. Corey, and Jeffrey R. Holt, Neuron, 2018 Aug 22;99(4):736-753

Pan et al., 2018 PDF

~~August 14, 2018~~

Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1

Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG. Scientific Reports, 2018 Aug 14;8(1):12124.